February 15, 2018

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In the antihypertensive and lipid-lowering treatment to prevent heart attack trial allhat study, the long-term cardiovascular morbidity and mortality benefit of a long-acting dihydropyridine calcium-channel blocker amlodipine , a thiazide-like diuretic chlorthalidone , and an ace inhibitor lisinopril were compared in a broad population of patients with hypertension at risk for coronary heart disease.

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We then used a proportional hazards model to determine the risk ratio for death during the trial for lisinopril versus chlorthalidone and for amlodipine versus chlorthalidone.

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Ace inhibitors like lisinopril decrease blood pressure level by reducing the creation of angiotensin ii, thereby relaxing arterial muscle and enlarging arteries.

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tell your doctor if you have kidney or liver disease, if you have had severe vomiting or diarrhea or think you may be dehydrated, and if you are taking angiotensin-converting enzyme ace inhibitors such as benazepril lotensin , captopril capoten , enalapril vasotec , fosinopril, lisinopril prinivil, zestril , moexipril univasc , perindopril aceon , quinapril accupril , ramipril altace , and trandolapril mavik ; or diuretics water pills .

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